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IBC Scientific Day -- 11th July 2018

Journée Scientifique de l'IBC - 11 juillet 2018 Une journée d'exposés scientifiques, de réseautage, et de discussions concernant la biologie computationnelle. Horaires: 9:15 - 17:30 Programme Lieu: Amphithéâtre du CNRS Adresse: CNRS | Délégat...

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Mathematical and Computational Evolution…

Mathematical and Computational Evolutionary Biology 2018

IBC is co-organising the 2018 edition of Mathematical and Computational Evolutionary Biology 2018, which will take place in St Martin de Londres from June 25-29th, 2018. This year focus is "Methods for Evolutionary Genomics". For more informaiton ab...

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10th Statistical Methods for Post Genomi…

10th Statistical Methods for Post Genomic Data (SMPGD) in Montpellier

Statistical Methods for Post Genomic Data (SMPGD) has taken place at Université de Montpellier on 11-12 January 2018 and was co-organised by members of IBC and supported by the IBC. Web: https://smpgd2018.sciencesconf.org/

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The Computational Biology Institute (IBC) aims at the development of innovative methods and software to analyze, integrate and contextualize large-scale biological data in the fields of health, agronomy and environment.  Scalable computational solutions able to handle this ever-increasing volume of data constitute the present and future bottleneck that may limit their economic impact. Several branches of research will thus be combined: algorithmics (combinatorial, numerical, highly parallel, stochastic), modeling (discrete, qualitative, quantitative, probabilistic), and data management and information retrieval (integration, workflows, cloud). Concepts and tools will be validated using key applications in fundamental biology (transcriptomics, structure and function of proteins, development and morphogenesis), health (pathogens, cancer, stem cells), agronomy (plant genomics, tropical agriculture), and environment (population dynamic, biodiversity).The project is divided into five complementary work-packages that include the main aspects of processing biological data on a large scale:

IBC is a multidisciplinary project center supported for five years (2012-2017) by the French "Investissements d'Avenir" Call and its trustees. IBC currently involves 65 permanent researchers with broad multidisciplinary spectrum, based in one company and fourteen laboratories of  Montpellier. IBC should become a privileged meeting place for computational biology and bioinformatics researchers, not only bringing together those involved with the original project, but also a large community of academic and industry researchers on regional, national and international levels. IBC activity will invite world-class researchers to collaborate with, organize scientific events, train young researchers, and promote results and exchange information with industrial partners.

Next seminar

Plenary sessions
IBC seminar - 8 October 2018, 14:00 - LIRMM Building 5 Room 1.124 Anthony Mathelier  -- http://mathelierlab.com
Group Leader - Computational Biology & Gene Regulation Group
Centre for Molecular Medicine Norway (NCMM)
Adjunct Researcher - Dept. of Cancer Genetics, Oslo University Hospital While most cancer studies focused on patient variations lying in protein-coding regions, the noncoding ~98% of the genome, containing cis-regulatory regions that control when and where genes are expressed, is largely unexplored. Transcription factors are key proteins binding to cis-regulatory regions to modulate the rate of gene transcription. Delineating the specific positions at which a TF binds DNA is of high importance in deciphering gene regulation. As cancer is a disease of disrupted cellular regulation, it is critical to analyze these regions to highlight patient somatic mutations and epigenetic modifications altering the gene regulatory program of the cells. In this talk, I will present our recent works on improving our capacity to predict direct TF-DNA interactions and highlighting somatic mutations and DNA methylation alteration that shift the regulation of protein coding and microRNA genes expression in cancer patients.

Label Ivestissement d'AvenirIBC is a project "Investissements d'Avenir" managed by University of Montpellier

Recent publications

Conferences

Mathematical and Computational Evolution…

MCEB 2017 - Mathematical and Computational Evolutionary Biology
12-16 June 2017 - IGESA, Porqueroles, South of France.

Official webpage: http://www.lirmm.fr/mceb2017/

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